![]() Results: The drug regimens remained unchanged in the two cohorts over the study period. Statistical analysis was achieved using Students t-test for continuous variables and Chi-squared test for categorical variables. HbA1c was collected and compared at one interval during follow-up postoperatively. Fasting glucose levels were compared every 3 months after transplantation for a year. All patients received a combination immunosuppressive regimen consisting of mycophenolate mofetil, corticosteroids and either tacrolimus or ciclosporin. Methods: A retrospective analysis of data from 52 patients who had received a heart transplantation at the Scottish heart transplant unit between January 2011 and August 2017. There is conflict around which calcineurin inhibitor, tacrolimus or ciclosporin, is more likely to induce diabetes. This in turn compounds the risk of cardiovascular disease. However, these drugs exhibit a variety of side effects, including hyperglycaemia. Currently, calcineurin inhibitors lie at the focal point of the immunosuppressive regimen. Aim: Immunosuppression has evolved since the first successful orthotopic heart transplant 50 years ago. ![]()
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